melancholia

Extreme, persistent sadness or hopelessness; depression. No longer in clinical use.

In pathology, a mental condition characterized by great depression combined with a sluggishness and apparent painfulness of mental action.

Same as melancholy, 2.

A kind of mental unsoundness characterized by extreme depression of spirits, ill-grounded fears, delusions, and brooding over one particular subject or train of ideas.

Deep sadness or gloom; melancholy.