manchineel Play nounA tropical American tree (Hippomane mancinella) having poisonous fruit and a milky sap that causes skin blisters on contact.nounA tree, Hippomane Mancinella, of moderate size, found in the West Indies, Central America, and Florida.nounA euphorbiaceous tree (Hippomane Mancinella) of tropical America, having a poisonous and blistering milky juice, and poisonous acrid fruit somewhat resembling an apple.nouna tree (Cameraria latifolia) of the East Indies, having similar poisonous properties.nounA tropical American tree, Hippomane mancinella, having apple–like, poisonous fruit, and a sap that causes blisters on contact with the skin