disaster Play nounA sudden accident or a natural catastrophe that causes great damage or loss of life. SYNONYMS accidentadversitybalebuffetcalamitycasualtycataclysmcatastrophecontretempsdifficultydistressheavy blowholocaustmisadventuremischancemisfortunemishantermishapproblemreversalreverse of fortuneruinruinationsetbackshockstroke of ill lucktragedytribulationtroublewoe