disable

dɪsˈeɪb(ə)l

verb

(of a disease, injury, or accident) limit (someone) in their movements, senses, or activities.

it’s an injury that could disable somebody for life

incapacitate,impair,damage,put out of action,render/make powerless,weaken,enfeeble,debilitate,indispose,make unfit,immobilize,hamstring,paralyse,prostrate,torpefy