malaise

A vague feeling of bodily discomfort, as at the beginning of an illness.

A general sense of depression or unease.

Uneasiness; discomfort; specifically, an indefinite feeling of uneasiness, often a preliminary symptom of a serious malady.

An indefinite feeling of uneasiness, or of being sick or ill at ease.

A feeling of general bodily discomfort, fatigue or unpleasantness, often at the onset of illness.