noun

the fact of no longer being on friendly terms or part of a social group.

the artist’s paintings from this period reflect his growing estrangement from his family

alienation,turning away,antagonism,antipathy,disaffection,hostility,unfriendliness,embitteredness,isolation,variance,difference,parting,separation,division,divorce,disunity,distance,break-up,split,breach,severance,schism