pestilence

noun

A usually fatal epidemic disease, especially bubonic plague.

A pernicious, evil influence or agent.

The disease called the plague or pest; also, any epidemic malignant disease.

That which is pestilential or pestiferous; that which produces or tends to produce malignant disease.

That which is morally pestilent; that which is mischievous, noxious, or malignant in any respect.